Genetics of Blood Type - Bombay Phenotype

Abstract

The Bombay Phenotype was first described in Bombay, India, and refers to a rare variation in the blood type inheritance pattern. It describes the phenomenon in which the type O child is born to the parents who are not type O themselves, and/or do not both carry an O allele. In such cases, the O blood type of the child is not based on the phenotype/genotype of the parents. This occurs when the child inherits a recessive H (h) antigen.

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• Role of H antigen
• Dominant and recessive H-antigens and their effect on blood type
• Role of FUT1 and FUT2 genes in bombay phenotype
• Incidence rates and geographic distribution

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