Genetics of Melanoma

Abstract

Melanoma is a type of skin cancer, which originates in melanocytes, the skin cells that give skin its pigment. Melanoma most commonly affects skin, but can sometimes be found in eyes, lining of nose, mouth and genitals. This cancer has a high potential for spread to many organs, such as spleen, liver and intestines. When found early, melanoma can be removed surgically and/or treated with chemotherapeutic drugs. If diagnosis is made late in the disease when extensive metastases occurred, melanoma is usually fatal.

This review article contains results from ten research articles published between 2002 and 2008.

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• Factors in development of Melanoma
• Incidence rates
• Familial Melanoma Syndromes
• Non-syndrome hereditary melanoma
• Difference from other familial cancer syndromes
• Individual gene involvement in melanoma
• Value of knowledge about melanoma genetics

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